Job Description

About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body's potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke's first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

Stoke's initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency).

Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company's proprietary approach.

Position Purpose:

We are seeking an enthusiastic and experienced bioinformatician to join the computational group focusing on mRNA splicing and antisense oligonucleotides. Drug discovery at Stoke begins with computational biology. As part of the early discovery team led by Stoke's co-founder, you will work collaboratively with data and experimental scientists to expand our analytical approaches in identifying therapeutic targets relevant to the TANGO technology.

Key Responsibilities:

• Assist in the development of strategic plans for analyzing and deciphering next-generation sequencing data, and apply modern computational biology approaches to advance Stoke's portfolio of therapeutic targets.
• Propose and develop analytical and visualization tools to deliver complex biological data.
• Build, deploy, and maintain bioinformatics applications on Amazon Web Services.
• Contribute to the development and maintenance of web applications to facilitate target identification and data analysis.
• Use computational tools to investigate novel approaches to upregulate gene expression.
• Provide program-specific support for pre-clinical and clinical groups, such as biomarker development and mechanism of action of ASO clinical candidates.
• Support a highly collaborative environment and promote positive teamwork among a team of scientists from different backgrounds.
• Communicate scientifically rigorous results clearly, verbally and in writing, both internally and externally.

Required Skills & Experience:

• A degree in bioinformatics, computational biology, computer science, mathematics, systems biology, or any related quantitative field.
• Previous experience in the biotech or pharma industry; 14 years with a bachelor's degree, 8 years with a master's degree, or 4 years with a Ph.D.
• Experience in and deep understanding of posttranscriptional gene expression regulation, including but not limited to RNA splicing, RNA surveillance. pathways, RNA binding proteins, and antisense oligonucleotides.
• Fluency in coding languages such as Python and R, including scientific modules and packages commonly used in bioinformatics. Familiarity with machine learning algorithms and applications is a plus.
• Direct experience in developing and maintaining reproducible analytical workflows for high-throughput sequencing assays such as bulk or single-cell RNA-Seq, eCLIP, or whole-genome sequencing using workflow management systems such as Snakemake or Nextflow.
• Management experience in leading computational scientists and interns.

Location(s):

This position is a hybrid position with an office setting based in our Bedford, MA location.

Travel:

This position will require approximately 5% travel.

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual's needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do.
Benefits & Compensation:

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

Interested candidates: Please visit Stoke's website to learn more and apply directly to the position listed on our Career Center.

For more information, visit stoketherapeutics.com or follow the company on X at @StokeTx.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.

Job Tags

Full time, Temporary work, Work at office,

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